The Method of Treating Cervicitis Associated with Human
Papilloma Virus

Korchazhkina Natalya Borisovna, Dobrokhotova Yuliya Eduardovna, Kruglova Larisa
Sergeevna, Dugieva Madina Zaudinovna, Moseshvili Gulnara Grigorevna, Ilina Irina
Yurevna, Petrova Mariya Sergeevna, Mikhajlova Anna Andreevna, Narimanova Metanat
Rafig kyzy (Russia, 2019)
Sexually transmitted diseases are a very important health and social problem nowadays. Human
papillomavirus (HPV) is one of the most common sexually transmitted infections. There
are many different types of HPV; some types go away on their own and do not cause any health
problems, but others can cause health problems, like genital warts and cancer.
One of the consequences of HPV infection can also be cervicitis, an inflammation of the
uterus, which appears in around 5-15% of infected women. One of the methods currently
used to treat HPV in cervicitis is the prescription medication Imiquimod. This cream applied
locally to the cervix enhances the immune system's ability to fight HPV. In a previous study, 20
out of 34 patients (58.8%) who had chronic HPV infection showed complete recovery after the
treatment with Imiquimod. The disadvantage of this method is the lack of local tissue
regeneration and the development of common side effects, such as redness and swelling at the
application site. Thus, a complementary treatment which can decrease these side-effects and
could potentially improve the effects of Imiquimod is required.

This study was done on 25 patients (20 - 35 years old) who were suffering from HPV-
associated cervicitis and who have been treated for at least 1 year without success. The

women from the study were treated with Bioptron Hyperlight Therapy for 10 minutes with
the device placed at 10 cm distance from the uterine cervix. Immediately after the
treatment, the cream containing Imiquimod was applied to the cervix. This procedure
was applied on alternative days until 12 treatments were completed.
One month after the end of treatment, all patients underwent colposcopic examination (a
procedure to examine the cervix, the lower part of the womb at the top of the vagina), cytological
test (evaluation of cells under a microscope, to determine what the cells look like and potentially
diagnose diseases at a cellular level) and the HPV test.
The results showed a normal colposcopy and cytological pattern in all patients. In addition, the
complete elimination of HPV virus was achieved in 21 (84%) out of 25 patients, 26%
more than in patients treated without Bioptron Hyperlight Therapy.
The synergic effect of Imiquimod and Bioptron treatments achieve a more effective elimination
of HPV because of their cumulative anti-inflammatory properties. The use of Bioptron
Hyperlight Therapy allows for a better and faster recovery of cervix tissue while avoiding the
side-effects of Imiquimod treatment.

The study highlights the multiple effects of Bioptron Hyperlight Therapy in regenerative
medicine, the enhancement of the immune system and the overall improvement of patients’ life
quality.