The Method of Treating Cervicitis Associated with Human Papilloma Virus
Korchazhkina Natalya Borisovna, Dobrokhotova Yuliya Eduardovna, Kruglova Larisa Sergeevna, Dugieva Madina Zaudinovna, Moseshvili Gulnara Grigorevna, Ilina Irina Yurevna, Petrova Mariya Sergeevna, Mikhajlova Anna Andreevna, Narimanova Metanat Rafig kyzy (Russia, 2019) Sexually transmitted diseases are a very important health and social problem nowadays. Human papillomavirus (HPV) is one of the most common sexually transmitted infections. There are many different types of HPV; some types go away on their own and do not cause any health problems, but others can cause health problems, like genital warts and cancer. One of the consequences of HPV infection can also be cervicitis, an inflammation of the uterus, which appears in around 5-15% of infected women. One of the methods currently used to treat HPV in cervicitis is the prescription medication Imiquimod. This cream applied locally to the cervix enhances the immune system's ability to fight HPV. In a previous study, 20 out of 34 patients (58.8%) who had chronic HPV infection showed complete recovery after the treatment with Imiquimod. The disadvantage of this method is the lack of local tissue regeneration and the development of common side effects, such as redness and swelling at the application site. Thus, a complementary treatment which can decrease these side-effects and could potentially improve the effects of Imiquimod is required.
This study was done on 25 patients (20 - 35 years old) who were suffering from HPV- associated cervicitis and who have been treated for at least 1 year without success. The
women from the study were treated with Bioptron Hyperlight Therapy for 10 minutes with the device placed at 10 cm distance from the uterine cervix. Immediately after the treatment, the cream containing Imiquimod was applied to the cervix. This procedure was applied on alternative days until 12 treatments were completed. One month after the end of treatment, all patients underwent colposcopic examination (a procedure to examine the cervix, the lower part of the womb at the top of the vagina), cytological test (evaluation of cells under a microscope, to determine what the cells look like and potentially diagnose diseases at a cellular level) and the HPV test. The results showed a normal colposcopy and cytological pattern in all patients. In addition, the complete elimination of HPV virus was achieved in 21 (84%) out of 25 patients, 26% more than in patients treated without Bioptron Hyperlight Therapy. The synergic effect of Imiquimod and Bioptron treatments achieve a more effective elimination of HPV because of their cumulative anti-inflammatory properties. The use of Bioptron Hyperlight Therapy allows for a better and faster recovery of cervix tissue while avoiding the side-effects of Imiquimod treatment.
The study highlights the multiple effects of Bioptron Hyperlight Therapy in regenerative medicine, the enhancement of the immune system and the overall improvement of patients’ life quality.